Population-Based Screening for Trisomies and Atypical Chromosomal Abnormalities: Improving Efficacy using the Combined First Trimester Screening Algorithm as well as Individual Risk Parameters

Ida Vogel; Ann Tabor; Charlotte Ekelund; Stina Lou; Jon Hyett; Olav Bjørn Petersen; The Danish Fetal Medicine Study Group; The Danish Cytogenetic Study Group
AIM: To examine the performance of the combined First Trimester Screening (cFTS) algorithm when outliers of 4 risk parameters (maternal age, nuchal translucency (NT) thickness, PAPP-A and ß-hCG) were included in the classification of "high-risk". METHODS: A retrospective analysis of singleton pregnancies undergoing cFTS between 2008 and 2011 in Denmark. Abnormal karyotypes were classified as trisomy 21 (T21), trisomy 13 (T13) and trisomy 18 (T18), sex chromosome aberrations and atypical abnormal karyotypes.

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År 2018
Udgiver Fetal Diagnosis and Therapy


Stina Lou

Stina Lou

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Stina Lou