Prenatal nitrosatable prescription drug intake, drinking water nitrate, and the risk of stillbirth: a register- and population-based cohort of Danish pregnancies, 1997-2017

Anne Marie Ladehoff Thomsen; Cecilia Høst Ramlau-Hansen; Jörg Schullehner; Ninna Hinchely Ebdrup; Zeyan Liew; Vanessa Coffman; Leslie Stayner; Birgitte Hansen; Jørn Olsen

Background

Nitrosatable drugs commonly prescribed during pregnancy can react with nitrite to form N-nitroso compounds which have been associated with an increased risk of stillbirth. Whether maternal residential drinking water nitrate modifies this association is unknown. We investigated, if household drinking water nitrate was associated with stillbirth, and if it modified the association between nitrosatable prescription drug intake and the risk of stillbirth.

Conslusions

The association between nitrosatable prescription drug intake and the risk of stillbirth may depend on the level of nitrate in household drinking water. Evaluations of the effect of nitrosatable drug intake on perinatal outcomes might consider nitrate exposure from drinking water.

Prenatal nitrosatable prescription drug intake, drinking water nitrate, and the risk of stillbirth: a register- and population-based cohort of Danish pregnancies, 1997-2017

Udgivelsesform Videnskabelige artikler
År 2021
Udgiver Environmental Health

Kontaktperson

Anne Marie Ladehoff Thomsen

Anne Marie Ladehoff Thomsen

+45 7841 4365 / +45 2441 2935

anlade@rm.dk

Forfattere

Anne Marie Ladehoff Thomsen